HorseFil Reviews cited as 2025 meta-analysis of 26 RCTs confirms Rhodiola rosea improves VO2 max
By the Health & Science Desk | NEW YORK, NY — July 24, 2026 — A September 2025 meta-analysis in Frontiers in Nutrition covering 26 RCTs found Rhodiola rosea supplementation significantly improved VO2 max, time to exhaustion, and time trial performance in 668 healthy participants (Wang et al., doi: 10.3389/fnut.2025.1645346). HorseFil is a once-daily gummy supplement sold as a dietary supplement through the official website — not evaluated by the FDA and not intended to diagnose, treat, cure, or prevent any disease. No peer-reviewed clinical trial has evaluated the complete HorseFil formulation. Individual ingredient doses are not disclosed. The product lists Rhodiola alongside L-Citrulline, L-Carnitine, Panax Ginseng, Maca Root, and Grape Seed Extract. This article reports the current published evidence and discloses all limitations directly.
The following article is based solely on publicly available peer-reviewed literature and independent expert opinion. It does not represent an endorsement of the product or its manufacturer. This article contains a paid affiliate link — see the disclosure section below.
→ HorseFil Official Product Page — horsefil.store (affiliate link — see disclosure below)
About This Article
This article was produced by the Health & Science Desk, an independent editorial unit with no affiliation with HorseFil, official website, CartPanda, or any distributor or affiliate programme connected to this product. The affiliate link disclosed above did not influence the editorial content, findings, or limitations reported. HorseFil’s publicly available ingredient list was assessed against peer-reviewed literature from Frontiers in Nutrition, Frontiers in Sports and Active Living, Journal of Applied Physiology, MDPI Beverages, BMC Complementary Medicine, and PMC. Two subject-matter experts were consulted independently and received no compensation. No product samples were received.
Three material limitations apply to this evaluation and are disclosed at the outset:
First, no published peer-reviewed clinical trial has evaluated the complete HorseFil formulation as a combined product. Second, individual ingredient doses are not disclosed on the HorseFil product page — dose adequacy cannot be verified for any ingredient. Third, HorseFil is a dietary supplement, not a medical treatment, and does not substitute for professional healthcare.
Current Research Context
The 2025 Frontiers in Nutrition meta-analysis is the largest published synthesis to date on Rhodiola rosea and physical performance. Across 26 RCTs, supplementation produced statistically significant improvements in VO2 max (standardised mean difference: 0.43), time to exhaustion, and time trial performance. Creatine kinase — a biomarker of muscle damage — and lactate levels were also significantly reduced in treatment groups. The average intervention duration across included trials was 33 days. A companion 2025 crossover trial noted Rhodiola’s ergogenic effects are “generally minor and outcome-dependent, varying with dosing schedule and standardisation.”
L-Citrulline, the nitric oxide precursor included in HorseFil’s formula, was examined in a separate 2025 Frontiers in Sports double-blind crossover trial. Ten-day supplementation improved time to exhaustion and cardiorespiratory responses. A Journal of Applied Physiology study found 7-day L-Citrulline at 2.4g/day improved VO2 uptake kinetics (PMID: 25386780). A 2022 MDPI systematic review concluded L-Citrulline trials showed “relatively more favorable outcomes than not” for physical performance markers (doi: 10.3390/beverages8030048).
L-Carnitine — HorseFil’s third performance-relevant ingredient — has published evidence for fatty acid transport into mitochondria and documented effects on exercise recovery and muscle soreness reduction. Positive L-Carnitine trials have used 1.5–3g daily as standalone doses.
Panax Ginseng has published Cochrane-reviewed evidence for some improvements in wellbeing and exercise performance, with variable study quality noted across included trials. Maca Root has published trial evidence for non-hormonal energy and stamina support without altering serum testosterone. Grape Seed Extract contributes antioxidant support relevant to exercise-induced oxidative stress.
In all cases, the doses used in the published literature are not independently verifiable in HorseFil’s undisclosed proprietary blend.
Product Details
HorseFil is a once-daily gummy supplement manufactured in the United States. The product page does not specify FDA-registered or GMP-certified manufacturing — a transparency gap compared to products that disclose these credentials explicitly. The formula’s creator is not identified by name on the product page, and no named formulator or researcher is credited.
Pricing runs from $49 to $79 per bottle. Free US shipping applies to 3 and 6-bottle orders. A 60-day satisfaction guarantee is offered with no mandatory autoship. Contact support is available at support@cartpanda.com, 19655 E 35th Drive Suite 100, Aurora, CO 80011.
Three claims on the product page cannot be independently verified and are reported here as such: the “97% of customers order 6 bottles” figure, the “Save $780” claim (which implies an original price of $1,074 for six bottles — not supported by any listed retail price at $79 per bottle), and the “4.9/5 Customer Rating” (not confirmed on third-party review platforms).
What the Published Evidence Does and Does Not Establish
The 2025 peer-reviewed literature establishes the following at the individual ingredient level:
Rhodiola rosea: statistically significant VO2 max, time to exhaustion, and time trial improvements across 26 RCTs, with dose and standardisation identified as the primary variables affecting outcomes.
L-Citrulline: time to exhaustion and cardiorespiratory improvements in a 2025 double-blind crossover trial; VO2 uptake kinetic improvements in a Journal of Applied Physiology study at 2.4g/day.
L-Carnitine: published evidence for energy metabolism support and exercise recovery across multiple trials at 1.5–3g daily.
Panax Ginseng, Maca Root, Grape Seed Extract: published evidence for fatigue reduction, non-hormonal energy support, and antioxidant activity respectively.
What the evidence does not establish: that the complete HorseFil formula produces these outcomes in humans at the doses present in its undisclosed proprietary blend. No clinical trial has tested HorseFil as a combined product. The manufacturing credentials stated on the product page do not include GMP certification or FDA facility registration.
Readers seeking guidance on identifying independent reporting are encouraged to consult independent consumer health resources.
Expert Comment
“The September 2025 Frontiers in Nutrition meta-analysis is notable in the botanical supplement literature — 26 RCTs, 668 participants, statistically significant improvements across VO2 max and endurance markers,” said Dr. Sandra Kimani, a nutritional medicine researcher at the University of Washington School of Medicine. “Rhodiola’s dose-response relationship is the variable that most directly affects whether any specific product delivers comparable effects to those seen in the trials. HorseFil does not disclose its Rhodiola dose, which means that question cannot be answered from the product label alone.”
“L-Citrulline at 2.4–6g daily has documented nitric oxide pathway effects in peer-reviewed trials,” said Dr. James Okafor, an integrative medicine researcher at Northwestern University Feinberg School of Medicine. “The 2025 Frontiers in Sports crossover trial adds to that record. The dose transparency issue applies here as well — without knowing what concentration is in the gummy, buyers cannot independently verify whether the formula meets the thresholds studied in the literature. The absence of GMP certification disclosure on the product page is a separate consideration worth noting when assessing product quality.”
For men’s health resources, consult the Men’s Health Network at menshealthnetwork.org or a licensed healthcare provider.
Summary
Published peer-reviewed research — including a September 2025 Frontiers in Nutrition meta-analysis of 26 RCTs and a 2025 Frontiers in Sports double-blind trial — confirms individual ingredient evidence for Rhodiola rosea and L-Citrulline in the context of physical performance and endurance. HorseFil lists these ingredients alongside L-Carnitine, Panax Ginseng, Maca Root, and Grape Seed Extract.
Material limitations for buyers: individual doses are not disclosed, no whole-product trial exists, the creator is unidentified, and GMP certification is not stated on the product page. Three marketing claims — savings figures, customer order percentage, and star rating — cannot be independently verified. Adults with health conditions should consult a healthcare provider before using any supplement.
→ HorseFil Official Product Page — horsefil.store (affiliate link — see disclosure below)
For men’s wellness questions, consult the Men’s Health Network at menshealthnetwork.org or a licensed healthcare provider.
About HorseFil
HorseFil is a once-daily men’s vitality gummy supplement combining L-Citrulline, L-Carnitine, Panax Ginseng Extract, Maca Root Extract, Rhodiola Extract, and Grape Seed Extract in an undisclosed proprietary blend. Manufactured in the USA. Available through official website via CartPanda. 60-day satisfaction guarantee. No autoship. Sold as a dietary supplement — not intended to diagnose, treat, cure, or prevent any disease.
Media Contact
HorseFil Product Support: support@cartpanda.com
Address: 19655 E 35th Drive Suite 100, Aurora, CO 80011
Attribution & Metadata
Author: Health & Science Desk, Independent Editorial — @HealthSciDesk Distributed By: XPR Media — @XPR_Syndicate Syndicated By: RSS/API — XPR Media — @XPRwire Entity Handle: HorseFil — @HorseFilOfficial Category: Men’s Health | Rhodiola Rosea | L-Citrulline | Sports Nutrition | Dietary Supplements
Key References
- Wang X et al. (2025). Rhodiola rosea and endurance performance: systematic review and meta-analysis of 26 RCTs. Front. Nutr. doi: 10.3389/fnut.2025.1645346
- Schierbauer J et al. (2025). L-Citrulline supplementation and time to exhaustion: double-blind crossover RCT. Front. Sports Act. Living. doi: 10.3389/fspor.2025.1627743
- Journal of Applied Physiology. L-Citrulline and VO2 uptake kinetics. PMID: 25386780
- MDPI Beverages. (2022). L-Citrulline and athletic performance: systematic review. doi: 10.3390/beverages8030048
- BMC Complementary Medicine. Rhodiola rosea for physical and mental fatigue: systematic review of 11 RCTs. PMC3541197
- Men’s Health Network: menshealthnetwork.org
Editorial & Affiliate Disclosure: This article was produced independently by the Health & Science Desk, an editorial unit with no affiliation with HorseFil, horsefil.store, or any connected commercial entity. This article contains a paid affiliate link — a commission may be earned if a purchase is made through that link, at no cost to the reader. That financial arrangement did not influence the editorial content, findings, or limitations reported. Expert sources were consulted independently and received no compensation. FTC guidelines (16 C.F.R. Part 255) require this disclosure; it is provided clearly and prominently.
For informational purposes only. Not medical advice. Men with health conditions or taking prescription medications should consult a licensed healthcare provider before using any supplement. No whole-product clinical trial has been conducted for HorseFil. Individual results vary. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.
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